Natural_combretastatins Combretastatin

-


combretastatin a-4


molecules fall combretastatin family share 3 common structural features: trimethoxy -ring, b -ring containing substitutents @ c3 , c4 , , [often] ethene bridge between 2 rings provides necessary structural rigidity. molecules such ethene bridge stilbenoids, molecules non-ethene bridge dihydrostilbenoids.


molecules c3 amino , hydroxyl substituents active, , molecules c4 hydroxyl or methoxy substituents cytotoxic. of natural products presently known combretastatin a-4 potent in regards both tubulin binding ability , cytotoxicity. combretastatin a-1 potent cytotoxic agent. molecule combretastatin b-1.








Comments

Post a Comment

Popular posts from this blog

Water_resources.2C_water_use_and_infrastructure Water_supply_and_sanitation_in_Burkina_Faso

-
the nakambe river in burkina faso in february 2009 during dry season national overview of water resources. water resources scarce in burkina faso. water availability varies between regions , seasons, year year. in south, average rainfall high 1,200mm during six-month wet season, while in north wet season lasts 3 months , rainfall 300mm. rivers in country carry water year around mouhoun river (black volta) , nakambe river (white volta), other rivers carrying water during wet season. building dams has been common way of storing water dry season, though evaporation can reach 2,000 mm/year causing substantial water losses open reservoirs. substantial portion of surface water resources shared neighboring countries. example, nakambe river - main source of supply capital, ouagadougou - , mouhoun river shared ghana. surface water resources vary between 8 billion cubic meters (bcm)/year in average year , 4 bcm in dry year. lower figure corresponds less 300 cubic meters per capita , year, be...
Read more

History Rogers_Park,_Chicago

-
1 history 1.1 native american roots 1.2 settlers 1.3 becoming part of chicago 1.4 neighborhood growth history native american roots the rogers park area developed on once convergence of 2 native american trails, known rogers avenue , ridge boulevard, predating modern metropolitan chicago. pottawatomi , various other regional tribes settled in rogers park season season. name of indian boundary park west of rogers park reflects history pottawattomie park near clark street , rogers avenue. settlers in 1809, karthauser inn established stagecoach stop , tavern. 1 of original settlers (1836) of area phillip rogers, operated toll gate beside home @ ridge , lunt avenues , traded , worked local tribes. during period 1844 1850 arriving settlers started farms along ridge in western portion of rogers park, avoiding flooded lowlands east. in 1870 rogers son-in-law, patrick i. touhy, sold 100 acres land speculators, including john farwell, luther greenleaf, stephen lunt, charles morse, , george est...
Read more

History Jefferson,_Maryland

-
the center of jefferson examined historic maps (griffith 1795; bond 1858; martenet 1865, 1885; lake 1873; usgs1910) depict jefferson on md 180 1795. designated trap town @ close of 18th century griffith (1795). local history suggests name derives large number of taverns operating @ time. purportedly, taverns situated @ both ends of town. consequently, traveler trapped on way in or out of town. the lewis mill complex , george willard house national register of historic places properties near jefferson.
Read more