Natural_combretastatins Combretastatin

combretastatin a-4

molecules fall combretastatin family share 3 common structural features: trimethoxy -ring, b -ring containing substitutents @ c3 , c4 , , [often] ethene bridge between 2 rings provides necessary structural rigidity. molecules such ethene bridge stilbenoids, molecules non-ethene bridge dihydrostilbenoids.

molecules c3 amino , hydroxyl substituents active, , molecules c4 hydroxyl or methoxy substituents cytotoxic. of natural products presently known combretastatin a-4 potent in regards both tubulin binding ability , cytotoxicity. combretastatin a-1 potent cytotoxic agent. molecule combretastatin b-1.