Metabolome Metabolomics
metabolome refers complete set of small-molecule metabolites (such metabolic intermediates, hormones , other signaling molecules, , secondary metabolites) found within biological sample, such single organism. word coined in analogy transcriptomics , proteomics; transcriptome , proteome, metabolome dynamic, changing second second. although metabolome can defined readily enough, not possible analyse entire range of metabolites single analytical method. first metabolite database(called metlin) searching m/z values mass spectrometry data developed scientists @ scripps research institute in 2005. in january 2007, scientists @ university of alberta , university of calgary completed first draft of human metabolome. catalogued approximately 2500 metabolites, 1200 drugs , 3500 food components can found in human body, reported in literature. information, available @ human metabolome database (www.hmdb.ca) , based on analysis of information available in current scientific literature, far complete. in contrast, more known metabolomes of other organisms. example, on 50,000 metabolites have been characterized plant kingdom, , many thousands of metabolites have been identified and/or characterized single plants.
each type of cell , tissue has unique metabolic ‘fingerprint’ can elucidate organ or tissue-specific information, while study of biofluids can give more generalized though less specialized information. commonly used biofluids urine , plasma, can obtained non-invasively or relatively non-invasively, respectively. ease of collection facilitates high temporal resolution, , because @ dynamic equilibrium body, can describe host whole.
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